dicentric

Davis and DiMarco are looking for dicentric chromosomes: ones that have two centromeres.

Chromosomes can become dicentric when they are exposed to radiation.

This may be because it is dicentric and prone to anaphase bridging, which would dovetail with the frequent occurrence of chromothripsis following BFB cycles in sporadic iAMP21 ALL.

In order to maintain stability and normal segregation at mitosis, one centromere of a dicentric chromosome needs to be inactive.

In order to maintain stability and normal segregation at mitosis, one centromere of a dicentric chromosome needs to be inactive.