Opechancanough

In 1622, though Chief Powhatan had died, his empire was still strong, led by his brother, Opechancanough.

Chief Opechancanough decided to wipe out the English once and for all.

Chief Opechancanough did mount one more large attack on the settlers, in 1644, but by then the European population had grown and the Indian population had been decimated.

Chief Opechancanough was captured and killed, and the Powhatan empire crumbled.

The third lasted from 1644 to 1646 and ended with the capture and assassination of Opechancanough.